| Ke Xiaoyan,Jia Tingzhen,Chen Xufang,et al.Clinical observation of iatrogenic acute radiation sickness[J].Chinese Journal of Radiological Medicine and Protection,1998,18(4):235-239 |
| Clinical observation of iatrogenic acute radiation sickness |
| Received:December 08, 1997 Revised:February 25, 1998 |
| DOI： |
| KeyWords:Iatrogenic acute radiation syndrome Stem cells Total body irradiation G-CSF |
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| Abstract:: |
| Objective Clinical observation of acute radiation sickness (ARS) induced by medical treatment in order to accumulate clinical experience .Methods The changes of peripheral blood indexes, temperature and clinical symptoms of 17 cases who were irradiated with 6.0-7.2Gy X-ray before peripheral blood stem cell transplantation (PBSCT) were observed. Results WBC counts began to decrease to below 1×109/L from 8th day after irradiation and maintained at this level for 4 days, or for 13.3 days if the patients did not receive G-CSF treatment.29.4% of patients ran a temperature higher than 38.5 ℃.After total environment protection and vigorous antibiotic treatment, all patients could successfully pass through the period of bone marrow depression without typical critical phase of ARS. Conclusion Auto peripheral blood stem cell transplantation and G-CSF treatment to reduce the time span for reconstruction of bone marrow, total environment protection and combined antibiotic treatment are the key point of sucessful treatment of PBSCT. |
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