| Li Mei ying,Zhang Yaozhen,Zhang Donghua,et al.Clinical report of four cases of acute radiation sickness in a 60Co radiation accident in Wuhan[J].Chinese Journal of Radiological Medicine and Protection,1998,18(4):230-234 |
| Clinical report of four cases of acute radiation sickness in a 60Co radiation accident in Wuhan |
| Received:October 17, 1997 Revised:February 20, 1998 |
| DOI： |
| KeyWords:Bone marrow form acute radiation sickness Radiation dose Cobalt-60γ-rays Radiation accident |
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| Abstract:: |
| Objective To sum up clinical experience from assessment of radiation dose, clinical course, diagnosis and treatment of four cases of acute radiation sickness (ARS) in a 60Co radiation accident on 13 November, 1992, in Wuhan, China.Methods Radiation doses were assessed by simulation test of accident site, thermoluminescent dosimetry of ruby, and analysis of chromosome aberration and micronuclear rates in peripheral blood.Diagnosis was based on analysis of irradiation doses, clinical manifestations and laboratory results.In therapeutical aspect, GM-CSF was administered on the basis of comprehensive treatment.Results Four cases of ARS, including 1 case of moderate degree on the severe side, 1 case of moderate degree and 1 case of mild degree bone marrow form, as well as 1 case of overexposure, were meticulously treated for 62 to 68 days. The patients' conditions took favourable turn. The therapeutic effects were good. Conclusion From the clinical point of view we stress that (1) as soon as it is possible to estimate the degree of severity of ARS accurate diagnosis should be made;(2) early comprehensive treatment should be given according to the therapeutic principles of National Standard GB8280-87;(3)to improve the curative effect, GM-CSF should be given at the right time. |
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