| Ruan Ming,Lu Chunlin,Zhang Shuo,et al.Adaptive response to and its time effect on radiation induced chromosome aberrations in mouse embryonic cells pre exposed to cadmium chloride[J].Chinese Journal of Radiological Medicine and Protection,1998,18(3):151-152 |
| Adaptive response to and its time effect on radiation induced chromosome aberrations in mouse embryonic cells pre exposed to cadmium chloride |
| Received:April 01, 1997 Revised:July 24, 1997 |
| DOI： |
| KeyWords:Adaptive response Cadmium chloride 60Co γ rays Embryonic cells |
| FundProject: |
| Author Name | Affiliation | | Ruan Ming | Dept.of Toxicology, Beijing Medical University, Beijing 100083, China | | Lu Chunlin | Dept.of Toxicology, Beijing Medical University, Beijing 100083, China | | Zhang Shuo | Dept.of Toxicology, Beijing Medical University, Beijing 100083, China | | 尹香君 | Dept.of Toxicology, Beijing Medical University, Beijing 100083, China |
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| Abstract:: |
| Objective To observe if cadmium chloride could induce cross adaptive response to and its time effect on cytogenetic damage of mouse embryonic cells caused by ionizing radiation.Methods The mice were pre treated with iv injection of cadmium chloride solution on gestation d 9, then they were exposed to 1.5cGy 60Coγ rays at different time intervals. Chromosome preparation was made on gestation d 10.Results 0.25-2.0mg Cd/kg body weight could induce resistance to cytogenetic damage of embryonic cells of mice caused by ionizing radiation and the adaptive response appeared 4 h after pre exposure, at 8h reached the peak, but 12 to 24h later synergism appeared.Conclusion Cadmium chloride could induce cross adaptive response to 60Co γ rays which had relations with time interval of ionizing radiation. |
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