| Wang Hong,Liu Shuzheng.Effect of low dose radiation on POMC transcription level in mouse hypothalamus and immune organs[J].Chinese Journal of Radiological Medicine and Protection,1998,18(3):145-147 |
| Effect of low dose radiation on POMC transcription level in mouse hypothalamus and immune organs |
| Received:December 31, 1996 Revised:March 17, 1997 |
| DOI： |
| KeyWords:Low dose radiation Hypothalamus POMC In situ hybridization |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| Objective To disclose the changes in mRNAtranscription level of POMCin the hypothalamus and immune organs after low dose radiation.Method In situ hybridization was used to examine the changes of POMCmRNAtranscription level in mouse hypothalamus and immune organs following whole body irradiation (WBI) with 75mGy X-rays.Results There was a basal expression of POMCmRNAin both the hypothalamus and immune organs.POMCmRNApositive neurone were located in the arcuate nucleus of hypothalamus.WBIwith 75mGy X-rays could significantly down regulate the POMCtranscription level that was remarkable within 1h and remained low in the observation period of 12h.POMCtranscription level in mouse immune organs increased with time within 8h after irradiation and then began to decrease but still remained at a higher than normal level.The changes of POMCtranscription level were more marked in the spleen than in other immune organs.Conclusion These findings suggest that the immediate decrease of POMCtranscription level in the hypothalamus might be the direct cause of the down regulation of the hypothalamus pituitary adrenocortical axis after WBIwith 75mGy X-rays, accompanied with an increase in POMCtranscription in immune organs. |
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