| Bai Ou,Liu Shuzheng.Effect of low dose radiation on Th1 and Th2 of thymocytes and splenocytes in mice[J].Chinese Journal of Radiological Medicine and Protection,1998,18(2):106-109 |
| Effect of low dose radiation on Th1 and Th2 of thymocytes and splenocytes in mice |
| Received:September 08, 1997 Revised:December 28, 1997 |
| DOI： |
| KeyWords:Low dose radiation IFN-γ I-L 6 Th1 Th2 Immunological stimulation |
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| Abstract:: |
| Objective To elucidate the possible mechanism of activation of helper T cells after low dose radiation (LDR) exposure,the influence of whole body irradiation (WBI) with 75mGy X-rays on Th1 and Th2 was studied.Methods Mice were irradiated at a dose rate of 12.5mGy/min,and IFN-γ and IL-6 mRNA levels of the mocytes and splenocytes were analyzed by dot blot and Northern blot hybridization.Results It was found that IFN-γ and IL-6 mRNA significantly increased after WBI with 75mGyX-rays.Conclusion The gene induction of cytokine profile after LDR indicates that activation of both Th1 and Th2 subtypes may be involved in the stimulation of immune functions by LDR. |
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