| Song Liangwen,Zhao Xiunan,Yang Ruibiao.Effect of angiotensin Ⅱ on cell proliferation and collagen synthesis following 60 Co irradiation[J].Chinese Journal of Radiological Medicine and Protection,1998,18(2):98-100 |
| Effect of angiotensin Ⅱ on cell proliferation and collagen synthesis following 60 Co irradiation |
| Received:September 17, 1996 Revised:December 13, 1996 |
| DOI： |
| KeyWords:60Co Irradiation Fibroblasts Proliferation Type Ⅰ collagen Angiotensin Ⅱ |
| FundProject: |
| Author Name | Affiliation | | Song Liangwen | Institute of Radiation Medicine, Beijing 100850 | | Zhao Xiunan | Institute of Toxicant and Drug, Beijing, China | | Yang Ruibiao | Institute of Radiation Medicine, Beijing 100850 | | 王德文 | Institute of Radiation Medicine, Beijing 100850 | | 崔雪梅 | Institute of Radiation Medicine, Beijing 100850 | | 高亚兵 | Institute of Radiation Medicine, Beijing 100850 | | 马宪梅 | Institute of Radiation Medicine, Beijing 100850 | | 唐朝枢 | Institute of Toxicant and Drug, Beijing, China |
|
| Hits: 2182 |
| Download times: 1413 |
| Abstract:: |
| Objective To explore the mechanism of 60 Co irradiation on cellular proliferation and synthesis of type Ⅰ pro-collagen protein in cultured human embryo lung fibroblasts(HELF).Method Cultured cells were divided into groups irradiated with different doses plus angiotensin Ⅱ(AⅡ) stimulation.Relationship of malondialdehyde(MDA) content in medium and extent of cellular proliferation were measured,immuno reactive material of intracellular A Ⅱ and type Ⅰ pro-collagen protein were displayed by method of immunocytochemistry,and image pattern analysis was made.Results Irradiation with 1—5Gy could stimulate cell proliferation and synthesis of type Ⅰ pro-collagen significantly;cell proliferation and type Ⅰ pro-collagen synthesis could be promoted by exogenous A Ⅱ.Conclusion Irradition can stimulate HELF to synthesize A Ⅱ,which stimulates cell proliferation and type Ⅰ pro-collagen synthesis.It may be related to HELF proliferation and-collagen synthesis induced by irradition. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
