| Bai Yunhong,Wang Dewen,Cui Xuemei.Transforming growth factor beta 1(TGF-β1) mRNA expression in radiation interstitial pneumonitis[J].Chinese Journal of Radiological Medicine and Protection,1998,18(2):95-97 |
| Transforming growth factor beta 1(TGF-β1) mRNA expression in radiation interstitial pneumonitis |
| Received:January 26, 1996 Revised:May 30, 1996 |
| DOI： |
| KeyWords:TGF Radiation Interstital pneumonitis In situ hybridization |
| FundProject:解放军总后勤部八五攻关课题 |
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| Abstract:: |
| Objective In order to study the role and significance of transforming growth factor beta 1(TGF-β1)mRNA in radiation interstitial pneumonitis (RIP),and explore the mechanism of RIP,the authors observed TGF-β1 mRNA expression in the rat lungs.Method Male Wistar rats were divided into two groups:the control and the irradiation group.The latter received thoracic irradiation of 30Gy.At 0.5,1,2,3,6 and 12 months after irradiation,rats were killed.Lung pathologic changes and expression of TGF-β1 mRNA were observed using in situ hybridization technique.Results Expression of TGF-β1 mRNA in the irradiated lungs increased,compared with that in the control group,particularly in fibrous proliferative phase(3—6 months after irradiation).Conclusion TGF-β1 is related to the development of RIP. |
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