| Zhu Shoupeng,Xiao Dong,Han Xiaofeng.Electron microscopic morphology and DNA chain fragmentation studies on apoptosis in bone tumor cells induced by 153Sm[J].Chinese Journal of Radiological Medicine and Protection,1998,18(2):89-91 |
| Electron microscopic morphology and DNA chain fragmentation studies on apoptosis in bone tumor cells induced by 153Sm |
| Received:September 29, 1997 Revised:December 15, 1997 |
| DOI： |
| KeyWords:Electron microscopy Morphology DNA chain fragmentation 153Sm EDTMP Internal irradiation Bone tumor cells Apoptosis |
| FundProject:国际原子能机构资助 |
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| Abstract:: |
| Objective To study the apoptosis and fraction of DNA chain fragmentation in bone tumor cells induced by 153Sm EDTMP.Methods Apoptosis in bone tumor cells exposed to different time periods of 153Sm EDTMP internal irradiation was observed by electron microscopic morphology and DNA chain fragmentation studies.Results It was demonstrated that the bone tumor cells internally exposed to 153Sm EDTMP displayed nuclear fragmentation,margination of condensed chromatin,and formation of membrane bounded apoptotic bodies.Our study showed that the percentage of DNA chain fragmentation increases in direct proportion to the duration of internal exposure to 153Sm EDTMP.Conclusion Apoptosis induced by 153Sm EDTMP in bone tumor cells was dependent on the time of 153Sm EDTMP exposure. |
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