.Adaptive response of EL-4 cells on their apoptosis and cell cycle induced by 0.075 Gy X-rays[J].Chinese Journal of Radiological Medicine and Protection,1998,18(2):80-81
Adaptive response of EL-4 cells on their apoptosis and cell cycle induced by 0.075 Gy X-rays
Received:January 14, 1997  Revised:June 02, 1997
DOI:
KeyWords:Radiation  EL-4 cells  Apoptosis  Cell cycle  Adaptive response
FundProject:国家自然科学基金
Author NameAffiliation
范冰 130021 长春, 白求恩医科大学卫生部放射生物重点实验室 
鞠桂芝 130021 长春, 白求恩医科大学卫生部放射生物重点实验室 
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Abstract::
      Objective To investigate whether or not adaptive response of EL-4 cells in their apoptosis and cell cycle could be induced by low dose X-rays. Methods Flow cytometry (FCM) was employed. Results It was found that the apoptosis was enhanced by 2 Gy X-rays 12 hour after irradiation accompanied by G0/G1 phase black. However, pre-irradiation with 0.075 Gy X-rays could reduce the level of apoptosis and G0/G1 phase block induced by 2 Gy when the interval between 0.075 Gy and 2 Gy radiation was 6 hours. Conclusion 0.075 Gy pre-exposure could induce adaptive response of apotosis and G1 arrest in EL-4 cells.
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