| Su Xu,Wan Hong,Liu Shuzheng.Effect of low dose radiation on expression of apoptosis related gene products[J].Chinese Journal of Radiological Medicine and Protection,1998,18(2):77-79 |
| Effect of low dose radiation on expression of apoptosis related gene products |
| Received:June 04, 1996 Revised:October 03, 1996 |
| DOI： |
| KeyWords:Apoptosis Thymocytes Low dose radiation p53 bcl-2 bax proteins |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| Objective To study the expression of p53,bcl-2 and bax proteins in thymocytes following low dose radiation (LDR) and to explore the molecular mechanism of radiation hormesis and dose effect “J” shape curve of apoptosis induced by radiation.Methods Kunming mice were subjected to whole body irradiation (WBI) with 75 mGy X-rays.The expression of p53,bcl-2 and bax proteins was analyzed by flow cytometry 24 hours after irradiation.Results It was found that the expression of p53 protein significantly decreased (P <0.005).The expression of bcl-2 protein showed slight but not significant increase,while expression of bax protein showed slight but not significant decrease.However,the ratio of bcl-2/bax was significantly increased (P <0.05).Conclusion The changes in expression of p53 and bcl-2/bax ratio after WBI with LDR indicate that p53 and bcl-2/bax play an important role in genic regulation on apoptosis induced by radiation.The results may provide significant data for elucidating the molecular mechanism of radiation hormesis and dose effect “J” shape curve of apoptosis induced by radiation. |
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