| Jia Weihua,Wang Jixian,Li Benxiao,Gao Zhiwei,Xu Jun,Zhang Jingyuan.A nested case-control study on female breast cancer risk among medical diagnostic X-ray workers in China[J].Chinese Journal of Radiological Medicine and Protection,1998,18(2):73-76 |
| A nested case-control study on female breast cancer risk among medical diagnostic X-ray workers in China |
| Received:September 25, 1997 Revised:November 20, 1997 |
| DOI： |
| KeyWords:Case-control study Breast cancer Ionizing radiation |
| FundProject: |
| Author Name | Affiliation | | Jia Weihua | Institute of Radiation Medical, Chinese Academy of Union Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | Wang Jixian | Institute of Radiation Medical, Chinese Academy of Union Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | Li Benxiao | Institute of Radiation Medical, Chinese Academy of Union Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | Gao Zhiwei | Institute of Radiation Medical, Chinese Academy of Union Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | Xu Jun | Institute of Radiation Medical, Chinese Academy of Union Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | Zhang Jingyuan | Institute of Radiation Medical, Chinese Academy of Union Medical Sciences, Peking Union Medical College, Tianjin 300192, China |
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| Abstract:: |
| Objectives To research whether prolonged or repeated low level ionizing radiation can induce female breast cancer or not and to investigate other risk factors related to breast cancer risk,a nested case control study was done.Methods 30 cases of breast cancers were enrolled in the study,4 normal persons were selected from X-ray workers as controls to match each case.Logistic regression model was used for risk analysis.Results ①Accumulative breast dose is a significant risk factor,odds ratio(OR) between two dose levels (10c Gy) is 1.73(95%CI=1.05—2.84).②ORs of other two factors,obesity and family history of breast cancer,are 4.07(P = 0.01) and 26.67(P =0.024) respectively.③Interaction may exist between occupational X-ray exposure and obesity or non lactation.Conclusions Long time and low level occupational X-ray exposure may relate to excess risk of female breast cancer among medical diagnostic X-ray workers.Family history of breast cancer and obesity are also the significant risk factors of the cancer.The existence of obesity and non lactation may enhance the effect of radiation induced breast cancer. |
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