| Zhang Jiaqing,Huang Qin,Ge Yong,Changhai Hospital,Shanghai,China.Endocrinological changes in five cases of acute radiation sickness followed up to five and a half years after radiation exposure[J].Chinese Journal of Radiological Medicine and Protection,1998,18(1):43-48 |
| Endocrinological changes in five cases of acute radiation sickness followed up to five and a half years after radiation exposure |
| Received:April 15, 1997 Revised:May 20, 1997 |
| DOI： |
| KeyWords:Acute radiation sickness Endocrinology |
| FundProject: |
| Author Name | Affiliation | | Zhang Jiaqing | Department of Biophysiology, Fudan University, Shanghai 200433, China | | Huang Qin | Department of Biophysiology, Fudan University, Shanghai 200433, China | | Ge Yong | Department of Biophysiology, Fudan University, Shanghai 200433, China | | Changhai Hospital | Department of Biophysiology, Fudan University, Shanghai 200433, China | | Shanghai | Department of Biophysiology, Fudan University, Shanghai 200433, China | | China | Department of Biophysiology, Fudan University, Shanghai 200433, China |
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| Abstract:: |
| Objective The functional changes of endocrine glands in five cases of acute radiation sickness(ARS) were observed up to five and a half years after60Co radiation accident. Methods Determinations of hormones were carried out by radioimmunoassay. Results The serum testosterone and total triiodothyronine levels were reduced significantly and plasma cortisol also decreased may be caused by the inhibition of administered dexamethasone.The radiation on the putuitary caused the decrease of pituitary hormones (ACTH, etc).But serum estradiol prolactin LH and FSH levels once elevated significantly.All these changes recovered gradually later to different extent.But the renin angiotensin aldosterone system had a very active, mainly hyperactivating, response. Conclusion Radiation had a siginificant effect on endocrine glands, but most of its changes were recovered five and a half years later, except the slight decrease of serum testosterone and hyperactivity of RAA axis. |
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