| Li Jinying,Zhang Weiping.Delayed effects of radiation on enzymes in erythrocytes[J].Chinese Journal of Radiological Medicine and Protection,1998,18(1):36-38 |
| Delayed effects of radiation on enzymes in erythrocytes |
| Received:April 15, 1997 Revised:May 20, 1997 |
| DOI： |
| KeyWords:Radiation damage Delayed effect Erythrocytes Enzyme activity |
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| Abstract:: |
| Objective To study the delayed effects of radiation on the enzymes in erythrocytes.Methods The activity of 8 enzymes, related glycolysis, hexose monophosphate shunt, nucleotide metabolism, redox reaction and esterase in erythrocytes of five patients with bone marrow form of acute radiation sickness(ARS) were assayed at 1, 2, 3 and 6 years after exposure to 60 Co radiation. Results The decreased activities of glucose 6 phosphate dehydrogenase(G6PD), pyruvate kinase(PK), NADH methemoglobin reductase (MR) during the stage of crisis and of acetylcholinesterase (ACE) during the stage of convalescence were recovered to varying extent, whereas the lowered activities of the first three enzymes in some cases remained unchanged.There was no correlation between the enzyme activity and the radiation dose as well as the age of the patients. Conclusion It is demonstrated that the delayed effects of radiation damage to erythrocyte enzymes are most significant in PK of glycolosis, G6PD of hexose monophosphate shunt and MR of redox reaction.It is suggested that the genes related to the synthesis of erythrocyte enzymes may be damaged by radiation. |
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