| Min Rui,Shen Qian,Liu Benti.Analysis of phenotype and function of peripheral blood lymphocytes for patients with acute radiation sickness during recovery stage[J].Chinese Journal of Radiological Medicine and Protection,1998,18(1):26-29 |
| Analysis of phenotype and function of peripheral blood lymphocytes for patients with acute radiation sickness during recovery stage |
| Received:April 15, 1997 Revised:May 20, 1997 |
| DOI： |
| KeyWords:Acute radiation sickness T cell phenotype Lymphocyte function Recovery stage |
| FundProject: |
| Author Name | Affiliation | | Min Rui | Department of RadiationMedirirne, The Seconditary Mfedical University, Shanghai 200433，China | | Shen Qian | Changhai Hospital, Shanghai 200433 China | | 刘本俶 | Changhai Hospital, Shanghai 200433 China | | Liu Benti | Department of RadiationMedirirne, The Seconditary Mfedical University, Shanghai 200433，China | | 孟祥顺 | Department of RadiationMedirirne, The Seconditary Mfedical University, Shanghai 200433，China | | 杨如俊 | Department of RadiationMedirirne, The Seconditary Mfedical University, Shanghai 200433，China | | 肖锦松 | Department of RadiationMedirirne, The Seconditary Mfedical University, Shanghai 200433，China | | 郭明珠 | Department of RadiationMedirirne, The Seconditary Mfedical University, Shanghai 200433，China | | 董俊瑞 | Department of RadiationMedirirne, The Seconditary Mfedical University, Shanghai 200433，China |
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| Abstract:: |
| Objective To research the peripheral blood lymphocyte functions in patients with acute radiation sickness during recovery stage. Methods Phenotype of lymphocytes was analysed with flow cytometry;the functions of T cells and NK cells were analysed by biological method through determination of 3H TdR incorporation. Results At four and a half years after radiation exposure the CD4+ T cell counts in patients' peripheral blood was still lower than those in normal controls;the patients whose exposure dose was over 4 Gy showed higher PB CD8+ T cell counts but a patient exposed at the age of 54 years showed obviously lower counts;during restoration, all patients had enhanced CD + 16 cell count and NK cell function. Conclusion The restoration of T cell functions for the patients seemed associated with exposure dose and patients' age at the time of exposure;the enhancement in the number and activity of the NK cells for the patients during restoration may play a significant role in cellular immune recovery. |
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