| Liu Benti,Zhang Weiping,Yang Jianmin,et al.Follow up observation of five cases of severe or moderate degree bone marrow form of acute radiation sickness in 60Co radiation accident in Shanghai[J].Chinese Journal of Radiological Medicine and Protection,1998,18(1):2-9 |
| Follow up observation of five cases of severe or moderate degree bone marrow form of acute radiation sickness in 60Co radiation accident in Shanghai |
| Received:April 15, 1997 Revised:May 20, 1997 |
| DOI： |
| KeyWords:60Coradiation Bone marrow form Acute radiation sickness Long term effect |
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| Abstract:: |
| Objective A 60Co radiation accident occurred in Shanghai on June 25, 1990.All the five victims including two suffering from severe degree and three from moderate degree of bone marrow form of acute radiation sickness, were clinically cured after the critical stage.They were followed up for 18 months to observe the late effect of radiation. Methods After discharge on Dec.3, 1990, they were subjected to periodical systematic examination and related treatment. Results The results of the early 18 months systematic periodical survey after the accident were as follows:(1)the values of blood and bone marrow picture, number of hemopoietic progenitors were all decreased;(2)the erythrocytoplasmic enzymes and protein composition of erythrocytic membrane were abnomal;(3)the immunologic function, especially the cellular immunity, was defective;(4)the crystalline lense appeared slightly opaque and retina vessels dilated;(5) on chromosome karyotype analysis most of remaining aberrations were of stable types and offered the major evidence of dose response relationship while the yields of dicentrics plus rings of instable type declined strikingly;(6)the microcirculation of nail fold and bulbar conjunctiva showed distal contractile dysfunction, while the levels of serum AT 1 and AT 2 did not return to nomal:(7) the number of spermatozoa was decreased in the semen, with a dose dependently decreased survival rate and mobility; and (8) some endocrinologic functions did not return tonormal. Conclusion Based on the above results, it is indicated that although these patients were clinically cured from the critical stage, they should be followed up for long term observation at molecular, cellular and whole body levels by multiple disciplines.The authors suggest a preliminary plan for long term follow up survey to evaluate biological effects of radiation. |
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