| Song Liangwen,Wang Dewen,Cui Xuemei,et al.Effect of iron,taurine and arginine on rat hepatic fibrosis[J].Chinese Journal of Radiological Medicine and Protection,1997,17(6):410-413 |
| Effect of iron,taurine and arginine on rat hepatic fibrosis |
| Received:June 24, 1996 Revised:November 13, 1996 |
| DOI： |
| KeyWords:Radiation hepatic fibrosis Taurine Iron agent Hydroxyproline Malondialdehyde L-arginine |
| FundProject: |
| Author Name | Affiliation | | Song Liangwen | Institute of Radiation Medicine, Beijing100850, China | | Wang Dewen | Institute of Radiation Medicine, Beijing100850, China | | Cui Xuemei | Institute of Radiation Medicine, Beijing100850, China | | Shigeru Okada | 日本冈山大学病理学部 | | 刘淼 | 日本冈山大学病理学部 | | 高亚兵 | Institute of Radiation Medicine, Beijing100850, China | | 熊呈奇 | Institute of Radiation Medicine, Beijing100850, China | | 徐琪寿 | Institute of Radiation Medicine, Beijing100850, China | | 鲁华玉 | Institute of Radiation Medicine, Beijing100850, China |
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| Abstract:: |
| Objective The promotive role of iron on pathogenesis of hepatic fibrosis and the protective role of taurine and L-arginine against hepatic fibrosis were studied.Methods The model of rat radiation hepatic fibrosis was used.Experimental rats were divided into 0Gy,30Gy,30Gy+iron,30 Gy+taurine and 30Gy+L arginine groups.Serum iron,liver tissue hydroxyproline(Hyp) and malondialdehyde (MDA) were measured one and three months respectively after irradition of hepatic tissue,production and distribution characteristics of hepatic tissne type Ⅰ and Ⅲ collagen were observed with a polarizing microscope.Results Administration of iron agent could significantly increase hepatic tissue MDA content and serum iron concentration,one month after irradiation ,hepatic tissue Hyp in 30Gy+iron group began to increase,and collagen in hepatic tissue obviously increased.Taurine and L arginine could reduce serum iron concentration and decrease production of hepatic fissue Hyp.Conclusion Exogenous iron agent could promote early development of radiation hepatic fibrosis;taurine and arginine could diminish pathologic alteration of hepatic fibrosis to a certain extent. |
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