| Li Xiaoying,Zhao Po,Wang Dewen,et al.Elevation of telomerase activity in chronic radiation ulcer of human skin[J].Chinese Journal of Radiological Medicine and Protection,1997,17(6):408-409 |
| Elevation of telomerase activity in chronic radiation ulcer of human skin |
| Received:September 23, 1996 Revised:December 16, 1996 |
| DOI： |
| KeyWords:Radiation skin ulcer Telomerase Cancer |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| Objective To investigate the levels of telomerase activity in chronic radiation ulcers of human skin and the possible relationship between the enzyme and cancer transformation.Method Using nonisotopic telomere repeat amplification protocol (TRAP),detections were performed in 20 cases of chronic radiation ulcers of human skin,5 cases of normal skin tissues and 5 cases of carcinoma.Results The positive rates for telomerase activity were 30.0% (6/20),0(0/5) and 100%(5/5) in chronic radiation ulcers of human skin,normal skin and carcinoma,respectively.The telomerase activity in radiation ulcer was weaker than in carcinoma.Conclusion The telomerase activity assay might be used as a marker for predicting the prognosis and the effect of treatment in chronic radiation ulcer of human skin. |
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