| Wang Baoqin,Wang Jue,Tang Hongling.Radioprotective effects of cytokines on neutron or γ ray irradiated mice and their mechanisms[J].Chinese Journal of Radiological Medicine and Protection,1997,17(6):404-407 |
| Radioprotective effects of cytokines on neutron or γ ray irradiated mice and their mechanisms |
| Received:December 30, 1996 Revised:May 30, 1997 |
| DOI： |
| KeyWords:Cytokines Fission neutron Radioprotection Mice |
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| Abstract:: |
| Objective The radioprotective effects of cytokines,IL-1β,TNF α and G-CSF,on fission neutron or γ ray irradiated mice were investigated and their protective mechanisms were explored.Methods The 30 day survival rate of mice was determined.The numbers of CFU-S and BM progenitor cells of mice were estimated.The levels of serum GM-CSF and the change of transformation function of murine splenic lymphocytes were examined.Results IL-1β or TNF α could obviously increase 30 day survival rate of 8.5 Gy Y-ray irradiated mice. Administration of IL-Iβ plus TNFα possessed synergistic effects.However,radioprotective effects of Iβ一is or TNFα decreased in neutron-irradiated mice. Simultaneous in-jection of IL-is and TNFα did not possess additive effects,G-CSF could also increase 3o-day survival rate of fission-neutron irradiated mice. Administration of IL-β,TNFα and G-CSF alone or combinedly could protect the hemopoietic and immunological functions of mice exposed to neutron or Y-ray radiation to acertain extent ,especially protect granulopoiesis. Conclusion Administration of IL-β,TNFα alone or si-multaneously could protect mice from Y-ray irradiation obviously,their radioprotective effect on fission-neutron irradiated mice reduced,and there were no additive effects. G-CSF could protect mice from neu-ron irradiation. The mechanisms of the radioprotective actions of these cytolrines might be related to their ability to alleviate the radiation injuries and promote the recovery of hemopoietic and immunofogical function of mice after radiation. |
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