| Wang Zhaoyue,Wang Shanxi,Jiang Jiagui.Effect of fractionated 60Coγ-ray irradiation on 8-epi-prostaglandin F2α in plasma and RBC membrane of dogs.[J].Chinese Journal of Radiological Medicine and Protection,1997,17(5):312-315 |
| Effect of fractionated 60Coγ-ray irradiation on 8-epi-prostaglandin F2α in plasma and RBC membrane of dogs. |
| Received:January 15, 1996 Revised:April 08, 1996 |
| DOI： |
| KeyWords:Irradiation injury 8-epi-prostaglandin F2α Plasma Malondialdehyde RBC membrane |
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| Abstract:: |
| Objective By observing the alteration of 8 epi prostaglandin F2α (8-epi-PGF2α ) in plasma and RBC membrane of dogs during and after γ irradiation, and comparing it with malondialdehyde (MDA), we aimed to assess the value of measuring its concentrations in realizing the irradiation induced lipid peroxidative reaction, and to detect the effect of superoxide dismutase (SOD) on this procedure. Methods 18 adult outbred dogs (6 dogs each were randomly assigned to low dose SOD treatment group, high dose SOD treatment group and control group) were irradiated with 60Coγ-rays at a dose of 0.6Gy per day for 5 days, and the concentrations of 8-epi-PGF2α and MDA in plasma and RBC membrane were assayed before, during, and after the irradiation. Results The mean plasma 8-epi-PGF2α level in dogs was significantly increased during the γ irradiation, and gradually decreased after the irradiation was ended, while the enhanced 8-epi-PGF2α concentration in RBC membrane was higher than that in plasma, and it reached the peak level at the 2nd day after the irradiation was ended and then started to decrease; SOD could markedly inhibit its increase. The levels of MDA in plasma and RBC membrane were not significantly changed. Conclusion 8-PGF2α can serve as a new and more sensitive index for reflecting the irradiation induced lipid peroxidative reaction. |
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