| Wang Lianyuan,Yao Shanqian,Liu Haichuan.Clinical analysis of patients with acute radiation syndrome due to total body irradiation or total lymphatic irradiation[J].Chinese Journal of Radiological Medicine and Protection,1997,17(4):260-263 |
| Clinical analysis of patients with acute radiation syndrome due to total body irradiation or total lymphatic irradiation |
| Received:December 05, 1995 Revised:April 05, 1996 |
| DOI： |
| KeyWords:Acute radiation syndrome Hemopoietic stem cell transplantation Colony-stimulating factors |
| FundProject: |
| Author Name | Affiliation | | Wang Lianyuan | General Hospital of PLA, Beijing 100853, China | | Yao Shanqian | General Hospital of PLA, Beijing 100853, China | | Liu Haichuan | General Hospital of PLA, Beijing 100853, China | | 楼方定 | General Hospital of PLA, Beijing 100853, China | | 曾逖闻 | General Hospital of PLA, Beijing 100853, China | | 陈国雄 | General Hospital of PLA, Beijing 100853, China | | 张伯龙 | General Hospital of PLA, Beijing 100853, China |
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| Abstract:: |
| bjective To study the severity of iatrogenic acute radiation syndrome, treatment,hematopoietic recovery and related complications in patients subjected to total body irradiation (TBI) or total lymphatic irradiation (TLI) prior to hematopoietic stem cell transplantation. Methods 100 tumor patients (91 with leukemia and 9 with other tumors),after receiving 500～1000cGy (in an average of 738 6cGy) of TBI or TLI with super high dose chemotherapy as conditioning regimen during the process of hemopoietic stem cell transplantation,developed severe or even extremely severe,mainly bone marrow form acute radiation syndrome. Results The patients' white blood cell count once dropped to (0～0.15)×109/L,platelet count fell to (1～17)×109/L,bone marrow was depleted with only a few non hemopoietic cells and rare hemopoietic cells,and a high risk of complicating with infection and hemorrage was observed.Treated with a variety of measures including protective isolation,supportive care,administration of growth factors such as GM-CSF or G-CSF,blood component transfusion and effective antibiotics, 92 cases restored their normal hemopoiesis,while 8 cases died of infection or hemorrage.The clinical course of these patients indicated that a majority of the patients with severe and extremetly severe,iatrogenic acute radiation syndrome involving bone marrow could restore their normal hemopoiesis,and hemopoietic stem cell transplantation played an important role in the treatment. Conclusion Hemopoietic stem cell transplantation and administration of growth factors are very useful for the treatment of acute radiation syndrome. |
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