| Wang Rongxian,Li Meijia,Zhuang Xianglian.Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine[J].Chinese Journal of Radiological Medicine and Protection,1997,17(4):250-252 |
| Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine |
| Received:May 28, 1996 Revised:October 04, 1996 |
| DOI： |
| KeyWords:Radioprotective agent Thiazolidine Cystamine |
| FundProject: |
| Author Name | Affiliation | | Wang Rongxian | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and The Peking Union Medical College, Tianjin 300192, China | | Li Meijia | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and The Peking Union Medical College, Tianjin 300192, China | | Zhuang Xianglian | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and The Peking Union Medical College, Tianjin 300192, China | | 胡璧 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and The Peking Union Medical College, Tianjin 300192, China | | 饶尔昌 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and The Peking Union Medical College, Tianjin 300192, China | | 宋小英 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and The Peking Union Medical College, Tianjin 300192, China | | 李淑珍 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and The Peking Union Medical College, Tianjin 300192, China | | 宋永良 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and The Peking Union Medical College, Tianjin 300192, China |
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| Abstract:: |
| bjective To improve physical and chemical properties of 2,2-dimethylthiazolidine hydrochloride (DMTD) and enhance the antiradiation effect. Methods Various organic salts of 2,2-dimethylthiazolidine and cystamine were synthesized.The drug was administered to mice before 9.03 Gy 60Co gamma-ray whole body irradiation for evaluation of radioprotective effects. Results Most of these compounds showed significant radioprotective effects.Among them,DMTD tartrate 250mg/kg given i.p.1 hour before irradiation increased the survival rate by 40%.Cystamine succinate 250mg/kg administered i,p.15 min.before irradiation increased the survival rate by 77.5%. Conclusion Cystamine succinate showed marked antiradiation effect.Further investigation is worthwhile. |
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