| Jing Aoxing,Wang Siying,Wei Daoyan.Mechanism of low level ionizing radiation in inhibiting B16 melanoma blood borne pulmonary metastasis[J].Chinese Journal of Radiological Medicine and Protection,1997,17(4):236-238 |
| Mechanism of low level ionizing radiation in inhibiting B16 melanoma blood borne pulmonary metastasis |
| Received:December 19, 1996 Revised:April 17, 1997 |
| DOI： |
| KeyWords:Low level ionizing radiation B16-melanoma cells Clearance Immune function |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| bjective To study the mechanism of low level ionizing radiation in inhibiting B16 melanoma blood borne pulmonary metastasis. Method 125I labelled B16 melanoma cells were used to investigate the effect of low dose X irradiation on the distribution and clearance of tumor cells in mice. Results After whole body 7.5 cGy X-irradiation,the clearance of tumor cells was siginificantly increased from lungs of mice.The residual numbers of tumor cells were markedly lower than those of control in blood,spleen,liver and lungs (P<0.05-0.01).The cytotoxicity of murine splenic NK cells,LTR and the phagocytosis of macrophages augmented significantly after the mice were irradiated with low dose X-rays. Conclusion These results suggest that the enhancement of NK cytotoxicity and macrophage phagocytotic function might be one of the important reasons why low dose radiation can accelerate the clearance of tumor cells from the lungs. |
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