| Ye Zhijia,Dong Yanlin,Luo Chenji,et al.Changes of interleukin-3 expression after combined radiation-burn injury in mice[J].Chinese Journal of Radiological Medicine and Protection,1997,17(4):230-232 |
| Changes of interleukin-3 expression after combined radiation-burn injury in mice |
| Received:July 25, 1995 Revised:April 10, 1996 |
| DOI： |
| KeyWords:Radiation injury Burn Combined radiation burn injury Interleukin-3 Gene |
| FundProject:国家自然科学基金 |
|
| Hits: 5363 |
| Download times: 2392 |
| Abstract:: |
| bjective To study the changes of IL-3 expression after 5Gy irradiation, 30% total body surface area burn and combined radiation burn injury in mice. Methods Northern dot blotting, production of mRNA, cell culture, assay of IL-3 biological activity, etc. Results The IL-3 mRNA was markedly decreased by 77% and 21% on the 3rd day and the 14th day after irradiation, respectively. The IL-3 protein was decreased by 83% and 36% on 3rd and 14th day, respectively. There was a significant inhibition of IL-3 expression on the 3rd day after simple burn and slight increase of IL-3 expression on the 14th day. In groups with combined injury, IL-3 was more than that in the irradiated groups but less than that in the groups with burn injury. The changes of IL-3 expression were parallel with the changes of bone marrow cells. Conclusion Inhibition of IL-3 expression is one of the reasons of hematopoietic failure caused by radiation and combined radiation burn injury in mice. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
