| Chen Xiaosui,Luo Xunyi,Zhou Lijun.Radioprotective effect of recombinant human CuZn-SOD on activities of antioxidases and immunocytes in irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,1997,17(3):189-192 |
| Radioprotective effect of recombinant human CuZn-SOD on activities of antioxidases and immunocytes in irradiated mice |
| Received:December 11, 1996 Revised:March 25, 1997 |
| DOI： |
| KeyWords:Radioprotection rhCuZn SOD Immunocytes Antioxidases Free radicals |
| FundProject: |
| Author Name | Affiliation | | Chen Xiaosui | Laboratory of Molecular Biology, Navy General Hospital, Beijing 100037, China | | Luo Xunyi | Laboratory of Molecular Biology, Navy General Hospital, Beijing 100037, China | | Zhou Lijun | Laboratory of Molecular Biology, Navy General Hospital, Beijing 100037, China | | 谢邦铁 | Laboratory of Molecular Biology, Navy General Hospital, Beijing 100037, China | | 王欲晓 | Laboratory of Molecular Biology, Navy General Hospital, Beijing 100037, China | | 郑辉 | 卫生部工业卫生实验所 | | 赵乃坤 | 卫生部工业卫生实验所 |
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| Abstract:: |
| Objective The radioprotective effect of recombinant human CuZn-superoxide dismutase (rhCuZn-SOD) was investigated. Method The changes of antioxidase and immunocyte activities were observed in mice given rhCuZn-SOD before and/or after 5-7 Gyγ-irradiation. Results rhCuZn SOD showed significant radioprotective effect on irradiated mice, including accelerating activities of CuZn-SOD, glutathione peroxidase (GSH-Px) and catalase (CAT) in blood and liver cells (P<0.01), reducing contents of lipid peroxidase (LPO), enhancing proliferative response of T lymphocytes to ConP<0.05), increasing the numbers of whole spleen lymphocytes, leucocytes and ralative lymphocyte counts in peripheral blood (P<0 05-0.01), and prolonging average survival time of 30 days. Conclusion Decrease of antioxidase activities and increase of free radicals may be main causes of irradiation induced peroxidation and damage to cell activities.The rhCuZn-SOD has radioprotective effect which may be due to its function of eliminating free radicals and the joint action of other antioxidases. |
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