| Yang Zhaohua,Sun Meizhen,Ni Zhenli,et al.Synthesis of bimolecule substituted phenols and their effect on rats for removal of radiothorium[J].Chinese Journal of Radiological Medicine and Protection,1997,17(3):178-181 |
| Synthesis of bimolecule substituted phenols and their effect on rats for removal of radiothorium |
| Received:December 16, 1996 Revised:January 25, 1997 |
| DOI： |
| KeyWords:Chelating agents Thorium-234 Decorporation drug |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Yang Zhaohua | China Institute for Radiation Protection, Taiyuan 030006, China | | Sun Meizhen | China Institute for Radiation Protection, Taiyuan 030006, China | | Ni Zhenli | China Institute for Radiation Protection, Taiyuan 030006, China | | 陈桂宝 | China Institute for Radiation Protection, Taiyuan 030006, China | | 罗梅初 | China Institute for Radiation Protection, Taiyuan 030006, China |
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| Abstract:: |
| Objectives To search for new therapeutic chelating agents for removal of incorporated radiothorium. Methods New chelating agents (bimolecule-substituted phenols) were synthesized through Mannich reaction.These compounds were administered i.m.to SD rats after i.v.injection of 234Th .Two days later the radiothorium was assayed and the excretion and retention rates were calculated.Results These chelating agents could increase the excretion of 234Th in urine and feces and decrease its retention in liver and skeleton of rats.Among them No.Ⅷ is the best one, which could promote excretion of 68%. 234Th after two days and the retention of 234Th deposited in the tissues (liver and skeleton) was only 11.7%, as compared with 87.6% in the control group. Conclusions The chelating agent No.Ⅷ is worth further investigation. |
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