| Su Xu,Zhang Yingchun,Wan Hong.Effects of low dose radiation on differentiation, activation and apoptosis of thymocytes in mice[J].Chinese Journal of Radiological Medicine and Protection,1997,17(3):162-165 |
| Effects of low dose radiation on differentiation, activation and apoptosis of thymocytes in mice |
| Received:December 30, 1996 Revised:January 04, 1997 |
| DOI： |
| KeyWords:Low dose radiation Immunoenhancement Cellular mechanism Thymocytes Flow cytometry |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Su Xu | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | Zhang Yingchun | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | Wan Hong | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 刘树铮 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China |
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| Abstract:: |
| Objective To elucidate the possible mechanism of immunoenhancement after low dose radiation (LDR), the differentiation, activation and apoptosis of thymocytes following low dose irradiation were studied. Method Kunming mice were whole body irradiated (WBI) with low dose X-rays.The expressions of CD4, CD8, TCR, CD3, IL 2R, (Ca2+) i, Bcl-2 Bax and apoptosis of thymocytes were analyzed by flow cytometry.Results It was found that the ratio of TH/TS showed no significant changes after LDR.Thymocyte apoptosis was not increased after LDR.The increase of Bcl-2/Bax ratio after LDR might be one of its mechanisms.LDR could expedites the process of differentiation of and facilitate the signal transduction in, thymocytes. Conclusion The results indicate that the mechanism of immunoenhancement might be related to the expedition of the maturation, differentiation and activation of thymocytes, thus up-regulating the capability of supplying more mature T lymphocytes to the periphery by the thymus after LDR. |
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