| BAI Yunhong,WANG Dewen,GONG Yifen,GE Guixiu,ZHANG Zhensheng,CUI Xuemei,YANG Zhihua,XIONG Chengqi,ZHU Maoxiang,LI Yanping.Early effects of selenium preparation on radiation pneumonia[J].Chinese Journal of Radiological Medicine and Protection,1997,17(2):88-90 |
| Early effects of selenium preparation on radiation pneumonia |
| Received:March 18, 1996 Revised:May 30, 1996 |
| DOI： |
| KeyWords:Radiation pneumonia Collagens Pathological study Selenium |
| FundProject: |
| Author Name | Affiliation | | BAI Yunhong | Institute of Radiation Medicine, Beijing 100850 | | WANG Dewen | Institute of Radiation Medicine, Beijing 100850 | | GONG Yifen | Institute of Radiation Medicine, Beijing 100850 | | GE Guixiu | Institute of Radiation Medicine, Beijing 100850 | | ZHANG Zhensheng | Institute of Radiation Medicine, Beijing 100850 | | CUI Xuemei | Institute of Radiation Medicine, Beijing 100850 | | YANG Zhihua | Institute of Radiation Medicine, Beijing 100850 | | XIONG Chengqi | Institute of Radiation Medicine, Beijing 100850 | | ZHU Maoxiang | Institute of Radiation Medicine, Beijing 100850 | | LI Yanping | Institute of Radiation Medicine, Beijing 100850 |
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| Abstract:: |
| Objective In order to provide experimental basis for drug efficacy of preventing and treating radiation pneumonia,the authors observed the early effects of selenium preparation on the radiation pneumonia.Method Wistar male rats were divided into three groups of 48 rats:the control group,the irradiated group and the irradiated plus selenium preparation treated group.The animals received thoracic irradiation of 15 Gy,and were killed at 0.5,1,2,3 months post irradiation.Lung tissues were processed for light microscopy and isolation of RNA.Expression of type Ⅰ（Ⅲ） collagen was evaluated by dot blot hybridization and image analysis technique.Results Pathological study showed marked lung injury in the irradiated group while only slight hyperemia,hemorrhage,exudation and thickeness of alveolar walls in the lungs of selenium preparation treated group.The synthesis of type Ⅰ and Ⅲ collagen mRNA also decreased in the selenium preparation treated group.Conclusion Selenium preparation could have protective and therapeutic effects on radiation pneumonia. |
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