| SONG Liangwen,CUI Xuemei,GAO Yabing,YANG Ruibiao,XIA Guowei,WANG Dewen.Production site of radiation-induced pulmonary fibrosis[J].Chinese Journal of Radiological Medicine and Protection,1997,17(2):84-87 |
| Production site of radiation-induced pulmonary fibrosis |
| Received:April 01, 1996 Revised:August 08, 1996 |
| DOI： |
| KeyWords:Radiation Pulmonary fibrosis Angiotensin Ⅱ Hydroxyproline Collagens |
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| Abstract:: |
| Objective Production site development and alterations of early pulmonay fibrosis were studied. Method Single irradiation was made at right thorax of rats with 0,15 and 30 Gy of γ irradiation, respectively.The rats were divided into three groups which were sacrificed 1,3,5 months post irradiation.Hydroxyproline in lungs was measured by biochemical method.Pulmonary type I and Ⅲ collagens were measured by polarization method.Distribution of angiotensin Ⅱ （AⅡ） in pulmonary tissues was displayed by immunohistochemical method. Results Extent of pulmonary fibrosis relatively increased with irradiation dose and time elapse after irradiation.Ratio of type I to type Ⅲ collagens increased with increasing fibrosis.Proliferating collagen fibers mainly came from fibroblasts of pulmonary bronchial and arteriolar adventitia,and extended into pulmonary parenchyma.Meanwhile,type I collagen substituted for type Ⅲ collagen in interstitium of pulmonary alveoli.AⅡ was positive for fibroblasts and macrophages in pulmonary interstitium. Conclusion Irradiation can stimulate fibroblasts in interstitum proliferation,and type I collagen substitutes for type Ⅲ collagen.Expression and synthesis of AⅡ in interstitium may promote the course of pulmonary fibrosis. |
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