| LIN Xingshi,LIU Yali,ZHANG Xiaoming,XIA Hongtian,SUN Xiaohua,SONG Chen,YUAN Mei.Treatment of radiation-induced interstitial pneumonia in rats with compound anisodine on pathological study[J].Chinese Journal of Radiological Medicine and Protection,1997,17(2):77-79 |
| Treatment of radiation-induced interstitial pneumonia in rats with compound anisodine on pathological study |
| Received:May 02, 1996 Revised:October 08, 1996 |
| DOI： |
| KeyWords:Radiation-induced interstitial pneumonia Anisodine Pathological study |
| FundProject: |
| Author Name | Affiliation | | LIN Xingshi | Cancer Research Laboratory, General Hospital of PLA, Beijing, 100853 | | LIU Yali | Medical School of Da Xing'an Ling | | ZHANG Xiaoming | Cancer Research Laboratory, General Hospital of PLA, Beijing, 100853 | | XIA Hongtian | Cancer Research Laboratory, General Hospital of PLA, Beijing, 100853 | | SUN Xiaohua | Cancer Research Laboratory, General Hospital of PLA, Beijing, 100853 | | SONG Chen | Cancer Research Laboratory, General Hospital of PLA, Beijing, 100853 | | YUAN Mei | Cancer Research Laboratory, General Hospital of PLA, Beijing, 100853 |
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| Abstract:: |
| Objective Interstitial pneumonia is a severe complication of radiation injury.In order to improve the therapeutic efficacy,we used compound anisodine （CA） to prevent and treat the radiation-induced pneumonia in rats. Method 45 Wistar rats were randomly divided into three groups: radiated group,CA treated group,and control group.The thoraces of rats in the radiated group and CA treated group received 30 Gy single exposure dose of 60Co γ radiation. On 2 days before irradiation,the rats of CA treated group were injected with CA subcutaneously once a day,until they were killed with other groups on days 15,30,50 after irradiation,respectively. Results The pathological morphology showed that the rats in the radiated group suffered from typical radiation-induced interstitial pneumonia,while the rats in the CA treated group had only slight reactions in their lungs and recovered quickly. Conclusions The experimental results indicate that in the early stage after radiation exposure,treatment and prevention of interstitial pneumonia in rats with CA is effective and CA can protect the lung tissues,prevent and relieve the radiation injury of lungs. |
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