| Li Qing,Li Guomin,Liu Shujun,et al.Pathological characteristics of extremely severe acute radiation injury in a patient's legs and hands after a very uneven accidental exposure to an extremely high dose of 192 Ir[J].Chinese Journal of Radiological Medicine and Protection,1997,17(1):22-25 |
| Pathological characteristics of extremely severe acute radiation injury in a patient's legs and hands after a very uneven accidental exposure to an extremely high dose of 192 Ir |
| Received:May 03, 1996 Revised:September 04, 1996 |
| DOI： |
| KeyWords:192Ir radiation source Acute radiation injury Skin Bone marrow Skeletal muscles |
| FundProject: |
| Author Name | Affiliation | | Li Qing | Department of Pathology, North Taiping Road Hospital, Beijing 100039 | | Li Guomin | Department of Pathology, North Taiping Road Hospital, Beijing 100039 | | Liu Shujun | Department of Pathology, North Taiping Road Hospital, Beijing 100039 | | Yang Yijing | Department of Pathology, North Taiping Road Hospital, Beijing 100039 | | Li Fumeng | Department of Pathology, North Taiping Road Hospital, Beijing 100039 | | 杨俊华 | 山西翼城县医院 |
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| Abstract:: |
| Objective The pathological characteritics of an extremely high dose radiation in the legs and hands of a patient is reported.Methods Routine section and HE staining.Results The patient was exposed to 192Ir γ-rays for 9 hours and 20 minutes,the activity of which was 2.76TBq.The amputations of the right thigh and left forearm had to be performed 8 days after the irradiation and the debridements and skin graftings were performed on the right hand and the inner side of left knee 55 days after the radiation.Microscopically,massive necroses of cells of the epidermis,cutaneous appendages,hypodermis and skeletal muscles,and haemorrghage in the dermis,hypodermis and skeletal muscles were seen in the local irradiated parts of the right shank.But the arrector pili muscles in the dermis of the right shank remained.On the fingers and the palm of the left hand,vacuolar degeneration and massive necrosis of the cells of epidermis were present with extensive neutrophil infiltration.Cysts of large or small size were formed from the necrotic cells,separating epidermis from dermis.There were degeneration and necrosis of glandular epithelium cells of sweat glands.Haemorrghage was present in dermis and hypodermis.All the hematopoietic tissues in the bone marrow in the upper ends of the tibia and fibula and in the lower ends of the femur,the radius and the ulna disapeared.Acute radiation ulcers were present on the skin of the left knee and on the skin of the thumb,index finger and middle finger of the right hand.Conclusions The extremely severe acute radiation injury caused by extremely high dose of 192Ir led to the necrosis of the extensive soft tissues deep to skeletal muscles and the disappearace of the hematopoietic tissues in the bone marrow. |
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