| Xie Huaijiang,Niu Rongjiu,Liu Xiaodong.Effects of X-ray irradiation combined with hyperthermia on human bone marrow cells[J].Chinese Journal of Radiological Medicine and Protection,1996,16(6):408-410 |
| Effects of X-ray irradiation combined with hyperthermia on human bone marrow cells |
| Received:October 19, 1995 Revised:April 05, 1996 |
| DOI： |
| KeyWords:Hyperthermia irradiation bone marrow cells |
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| Abstract:: |
| This paper reports on the effects of X-ray irradiation combined with hyperthermia on human bone marrow cells (BMC) in vitro. Observation was made on the morphology of treated cells under optic microscope and ultrastructural changes under electron microscope. The change was not obvious at first after treatment i, e, only the vacuolar degeneration was observed in a few cells under the EM. The survival of BMC alone after irradiation decreased with increase of the irradiation dose. The morphological changes included vacuolar degeneration of cells, swelling of mitochondria, and desintegration of nuclear membranes. The survival rate of BMC after irradiation combined with hyperthermia was significantly lower than that after treatment by either of them alone (P< 0.01 ). The morphological changes were as follows: the cell structure was destroyed, the cell support system and cell organelles were destroyed, the cell membrane and nuclear membranes were destroyed, and the cell plasma and nuclear sap overflowed . |
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