| Peng Ruiyun,Wang Dewen,Li Yanpong.Quantitative pathological studies on hone marrow radiation injury treated with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in beagle dogs[J].Chinese Journal of Radiological Medicine and Protection,1996,16(6):402-404 |
| Quantitative pathological studies on hone marrow radiation injury treated with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in beagle dogs |
| Received:October 07, 1995 Revised:January 26, 1996 |
| DOI： |
| KeyWords:rhGM-CSF bone marrow radiation image analysis pathology |
| FundProject: |
| Author Name | Affiliation | | Peng Ruiyun | Institute of Radiation Medicine, Beijing, 100850 | | Wang Dewen | Institute of Radiation Medicine, Beijing, 100850 | | Li Yanpong | Institute of Radiation Medicine, Beijing, 100850 | | 熊呈琦 | Institute of Radiation Medicine, Beijing, 100850 | | 夏国伟 | Institute of Radiation Medicine, Beijing, 100850 | | 张振声 | Institute of Radiation Medicine, Beijing, 100850 | | 罗庆良 | Institute of Radiation Medicine, Beijing, 100850 | | 董波 | Institute of Radiation Medicine, Beijing, 100850 |
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| Abstract:: |
| By means of nuclear organizer region associated protein (Ag-nor) Staining and image analysis, we quantitatively studide the effect of rhGM-CSF on bone marrow hemopoiesis of 14 beagle dogse irradiated with 5.5Gy 60 Coγ-rays and treated with low (10μg/kg.d) and high (20μg/kg. d) dose of rhGM-CSF for 20 days. The dogs were sacrificed in 30 days after radiation to remove sternum. The results showed that high dose of rhGM-CSF obviously improved the reconstitution of bone marrow hemopoiesis. It may increase hemopoietic cells and monocyte lineages, and promote proliferation of these cells. All of these changes were compared with those of the controls, and the results indicate that the differences were significant (P< 0.01 or< 0.05) . The authors hold that rhGM-CSF can be used to treat bone marrow radiation injury. The probable mechanism of rhGM-CSF therapy is discussed. |
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