Wang Deping,Shen Wenmei,Tian Yaping,Wang Chenbing.Experimental study on anti-radiation effectivenss of astragalus total flavonoids[J].Chinese Journal of Radiological Medicine and Protection,1996,16(6):399-401 |
Experimental study on anti-radiation effectivenss of astragalus total flavonoids |
Received:October 19, 1995 Revised:January 22, 1996 |
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KeyWords:Total flavonoids astragalus mon gholicus Bunge intraoperative radiotherapy superoxide dismutase malonyldialdehyde |
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Abstract:: |
The anti-radiation effectiveness of total flavonoids of astragalus mongholicus Bunge(TFA)has been studied with the model of intraoperative radiotherapy of imitative lung cancer.The results showed that some tissues have been protected from damage by intravenous administration of TLA before rsdiotherapy.The malonyldialdebyde concentration decreascd in trssue homogenate,while the superoxide dismutase activity did not fall.The results also show that the intraoperative radiotherapy may generate a large number of free radicals, which induce tissue and cell damage not only at the place of direct irradiation,but also at the remote places.It is suggested that the TLA has the effect of anti-radiation.The mechanism may be related to TLA properties such as anti-oxidation and scavenging of free radicals. |
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