Wang Deping,Shen Wenmei,Tian Yaping,Wang Chenbing.Experimental study on anti-radiation effectivenss of astragalus total flavonoids[J].Chinese Journal of Radiological Medicine and Protection,1996,16(6):399-401
Experimental study on anti-radiation effectivenss of astragalus total flavonoids
Received:October 19, 1995  Revised:January 22, 1996
DOI:
KeyWords:Total flavonoids  astragalus mon gholicus Bunge  intraoperative radiotherapy  superoxide dismutase  malonyldialdehyde
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Author NameAffiliation
Wang Deping 100853 北京,解放军总医院生化科 
Shen Wenmei 100853 北京,解放军总医院生化科 
Tian Yaping 100853 北京,解放军总医院生化科 
Wang Chenbing 100853 北京,解放军总医院生化科 
林善文 北京解放军总医院胸外科 
丁保国 北京解放军总医院胸外科 
周乃康 北京解放军总医院胸外科 
孙玉鹗 北京解放军总医院胸外科 
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Abstract::
      The anti-radiation effectiveness of total flavonoids of astragalus mongholicus Bunge(TFA)has been studied with the model of intraoperative radiotherapy of imitative lung cancer.The results showed that some tissues have been protected from damage by intravenous administration of TLA before rsdiotherapy.The malonyldialdebyde concentration decreascd in trssue homogenate,while the superoxide dismutase activity did not fall.The results also show that the intraoperative radiotherapy may generate a large number of free radicals, which induce tissue and cell damage not only at the place of direct irradiation,but also at the remote places.It is suggested that the TLA has the effect of anti-radiation.The mechanism may be related to TLA properties such as anti-oxidation and scavenging of free radicals.
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