Feng Leping,Chen Jun,Dong Yonglan,et al.Effects of low dose irradiation on tumor cell kinetics and anti-tumor efficacy of mitomycin[J].Chinese Journal of Radiological Medicine and Protection,1996,16(6):393-395
Effects of low dose irradiation on tumor cell kinetics and anti-tumor efficacy of mitomycin
  
DOI：
KeyWords:Low dose irradiation  cell kinetics  mitomycin  programmed cell death
FundProject:国家自然科学基金
Author NameAffiliation
Feng Leping 130021 长春,吉林省肿瘤研究所 
Chen Jun 130021 长春,吉林省肿瘤研究所 
Dong Yonglan 白求恩医科大学放射医学研究所 
苏士杰 白求恩医科大学放射医学研究所 
董永兰 130021 长春,吉林省肿瘤研究所 
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Abstract::
      The changes of carcinoma cell cycle distribution were induced in vitro and in vivo by low dose(0.05Gy) X-ray irradiation. The percentages of the cells in G0/G1 phases tended to increase and that in S phase decreased. The extent of accumulation of cells in G1 phase was dose associated with programmed cell death (PCD) . It is indirectly showed in this study that low dose X-irradiation can impel the malignant cells to proceed to PCD. The result also demonstrated that low dose X - irradiation enhanced efficacy of mitomycin in killing malignant cells.
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