Feng Leping,Chen Jun,Dong Yonglan.Effects of low dose irradiation on tumor cell kinetics and anti-tumor efficacy of mitomycin[J].Chinese Journal of Radiological Medicine and Protection,1996,16(6):393-395 |
Effects of low dose irradiation on tumor cell kinetics and anti-tumor efficacy of mitomycin |
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DOI: |
KeyWords:Low dose irradiation cell kinetics mitomycin programmed cell death |
FundProject:国家自然科学基金 |
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Abstract:: |
The changes of carcinoma cell cycle distribution were induced in vitro and in vivo by low dose(0.05Gy) X-ray irradiation. The percentages of the cells in G0/G1 phases tended to increase and that in S phase decreased. The extent of accumulation of cells in G1 phase was dose associated with programmed cell death (PCD) . It is indirectly showed in this study that low dose X-irradiation can impel the malignant cells to proceed to PCD. The result also demonstrated that low dose X - irradiation enhanced efficacy of mitomycin in killing malignant cells. |
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