| Qiu Liling,Liu Xiaolan,Zhao Zhenhu.Effect of different doses of rhIL-6 on peripheral blood recovery in irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,1996,16(6):389-392 |
| Effect of different doses of rhIL-6 on peripheral blood recovery in irradiated mice |
| Received:January 02, 1996 Revised:April 16, 1996 |
| DOI： |
| KeyWords:Recombinant human interleukin-6 γ-ray irradiation peripheral blood count |
| FundProject: |
|
| Hits: 2456 |
| Download times: 1662 |
| Abstract:: |
| The effects of recombinant human interleukin-6 (rhIL-6) on the recovery of peripheral blood picture in 6.5Gyγ-ray irradiated( 132-127. 7R/min) C57BL/6J mice at the age of 80-90 days were studied. Group 1 served as the control and groups 2-5 were injected subcutaneously with rhIL-6 twice daily at doses of 10,200,500 and 1000μg -1 kg-1d-1, respectively, starting from 30 min after irradiation for 4 consecutive days. Peripheral WBC, RBC, and PLT counts, hemoglobin and hematocrit were determined before and 5,11,14,18,22 and 30 days after irradiation. It was shown that although the time of nadir emergence and the onset of recovery were similar in all the five groups, the nadir values were higher and the recovery was better, both being dose-dependent, in the IL-6 treated groups than in the control.Significant dose-response regression equations were obtained for WBC count on day 22,for RBC count on days 14 and 18, for PLT count on days 11 and 18.Our studies show that IL-6 is a candidate of thrombopoietic factor for treatment of radiation-induced thrombocytopenia. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
