| Yang Suhong,Xiang Xiaoqiong,Zhou Pingkun.Radiosensitization effect of ADP-ribose trans ferase inhibitor on human tumor cells[J].Chinese Journal of Radiological Medicine and Protection,1996,16(6):385-388 |
| Radiosensitization effect of ADP-ribose trans ferase inhibitor on human tumor cells |
| Received:November 06, 1995 Revised:March 18, 1996 |
| DOI： |
| KeyWords:Aminobenzamide cellular radiosensitivity DNA double strand break pulsed field gel electrophoresis |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| Radiosensitization effect of 3-aminobenzamide( 3-AB), a specific inhibitor of ADP-ribose transferase( ADPRT), on cell colony formation and DNA double strand break (DSB), repair of human tumor cells was studied. Results showed that 3-An reduced cell survival and checked DNA DSB repair, mainly the slow phase, but did not affect initial DNA DSB level, Good correspondence between cell survival fraction and DNA DSB repair ratio indicates that DNA DSB and its repair detected by pulsed field gel electrophoresis can be used to calculate cellular radiosensitivity . |
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