| Song Shuqiang.Effect of whole-body irradiation on wound macrophages and role of phenytoin sodium[J].Chinese Journal of Radiological Medicine and Protection,1996,16(5):317-319 |
| Effect of whole-body irradiation on wound macrophages and role of phenytoin sodium |
| Received:January 03, 1996 Revised:March 15, 1996 |
| DOI： |
| KeyWords:Irradiation Phenytion sodium Wound healing Macrophages |
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| Abstract:: |
| Macrophages play an important role in wound healing, The effect of 6Gy whole-body irradiation on wound macrophages and the role of phenytoin sodium were studied by making an incision on rat dorsum, into which polyvinyl alcohol sponges were implanted.It was found that after irradiation the phagocytic function of wound macrophages, the release of tumor necrosis factor (TNFα) and interleukin-1(IL-1) from wound macrophages, as well as the number of macrophages in wound were significantly decreased on days 3,5and 8 after wounding.Phenytoin sodium significantly increased the number of wound macrophages, improved the phagocytic function of macrophages and promoted release of TNFα and IL-1 from wound macrophages on days 3, 5 and 8 after wounding, no matter whether rats were irradiated or not.The results indicated that the important mechanism of impairing wound healing by whole-body irradiation was that the number and function of wound macrophages were decreased in early stage of wound healing.The role of phenytoin sodium in wound healing was increasing the number of wound macrophages and improving their function. |
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