| Fu Haiqing,Li Xiuyi,Li Youjun.Whole-body low dose irradiation suppresses cancer cell dissemination in mice[J].Chinese Journal of Radiological Medicine and Protection,1996,16(5):307-309 |
| Whole-body low dose irradiation suppresses cancer cell dissemination in mice |
| Received:October 01, 1995 Revised:February 13, 1996 |
| DOI： |
| KeyWords:Low dose radiation Cancer cells NK cells IL-2 secretion |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Fu Haiqing | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun, 130021 | | Li Xiuyi | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun, 130021 | | Li Youjun | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun, 130021 | | 刘树铮 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun, 130021 |
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| Abstract:: |
| Lewis lung carcinoma or B16melanoma cells were injected into the retrobulbar vein of mice 24h after whole-body irradiation (WBI) with 50, 75 , 100 or 150 mGy X-rays.The dissemination of the cancer cells as evaluated by counting the tumor nodules on the lung surface 14d after injection was found to be markedly decreased in the irradiated rnice as compared with the sham-irradiated control.In mice given 75 mGy WBI 24h before injection of Lewis lung carcinoma cells the splenic NK cell activity and IL-2 secretion were found to be potentiated 2-6 days after irradiation in comparison with the sham-irradiated mice which received the same number of tumor cells.The results suggest that low dose radiation might suppress cancer cell dissemination via the enhancement of immune rcactivity. |
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