| Jin Aoxing.Anti-metastasis effect of low-level ionizing radiation and possibility of its clinical application[J].Chinese Journal of Radiological Medicine and Protection,1996,16(5):299-301 |
| Anti-metastasis effect of low-level ionizing radiation and possibility of its clinical application |
| Received:October 19, 1995 Revised:July 26, 1996 |
| DOI： |
| KeyWords:Low-level ionizing radiation Anti-metastasis Tumor-bearing mice Cyclophosphamide |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Jin Aoxing | Department of Nuclear Medicine, Anhui Medical University, Hefei, 230032 | | 魏道严 | Department of Nuclear Medicine, Anhui Medical University, Hefei, 230032 | | 汪思应 | Department of Nuclear Medicine, Anhui Medical University, Hefei, 230032 | | 黄帼 | Department of Nuclear Medicine, Anhui Medical University, Hefei, 230032 |
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| Abstract:: |
| Reduction of pulmonary metastases was observed in tumor-bearing mice exposed to low-dose whole body X-irradiation.The anti-metastasis was better when low-dose X-irradiation was used in combination with low-dose cyclophosphamide.The activities of murine splenic NK cells and II-2- induced LAK cells, and the reactivity of splenocytes to IL-2 increased significantly in tumor-bearing mice treated with low-dose X-irradiation.These anti-tumor immune fuctions were also augmented in the mice treated with both low-dose X-irradiation and cyclophosphamide.These results domonstrated that low-dose X-irradiation had effective antimetastastic effect through the activation of the in vivo anti-tumor immunity, thereby providing a reliable evidence for the possibility of its clinical application. |
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