| Tong Xin.Radiation-induced lymphocyte apoptosis and its inhibition by trolox[J].Chinese Journal of Radiological Medicine and Protection,1996,16(5):293-295 |
| Radiation-induced lymphocyte apoptosis and its inhibition by trolox |
| Received:November 06, 1995 Revised:March 13, 1996 |
| DOI： |
| KeyWords:Apoptosis Irradiation Trolox Human peripheral lymphocytes |
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| Abstract:: |
| The ability of radiation to induce apoptosis and the effect of trolox, a water soluble vitamin E analog, on this induction were studied in human peripheral lymphocytes in vitro.Trolox was most effective in inhibiting DNA fragmentation when added to cells within 30 min post-irradiation.Application of trolox only before or during irradiation did not prevent DNA fragmentation, suggesting that it does not work by scavenging free radicals generated during radiation exposure.Incubation of the irradiated cells with trolox for 2h postirradiation was sufficient to prevent DNA fragmentation, if trolox was added within 30 min post-irradiation.These results indicate that the early ’ key’ step of programmed cell death can be inhibited irreversibly by trolox. |
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