| Zhou Guixia,Sun Jianping,Ou Guangmin,et al.Effect of irradiation,hyperthermia and chemotherapy on murine lewis tumour[J].Chinese Journal of Radiological Medicine and Protection,1996,16(4):243-245 |
| Effect of irradiation,hyperthermia and chemotherapy on murine lewis tumour |
| Received:January 03, 1995 Revised:April 14, 1996 |
| DOI： |
| KeyWords:Irradiation hyperthermia Lewis tumor platinum diamlinodichloride |
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| Author Name | Affiliation | | Zhou Guixia | General Hospital of PLA, Beijing, 100853 | | Sun Jianping | General Hospital of PLA, Beijing, 100853 | | Ou Guangmin | General Hospital of PLA, Beijing, 100853 | | Zeng Diwen | General Hospital of PLA, Beijing, 100853 | | 王连元 | General Hospital of PLA, Beijing, 100853 |
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| Abstract:: |
| We performed an experiment to study the effect of irradiation, hyperthermia and chemotherapy,alone or in different combinations,on weight,tumor volume,skin response and histological change of mice in order to find the best methed for treating Lewis tumor.We used 9 Mev electron beam irradiation in single doses of 6.8 and 10Gy, hyperthermia treatment at 43℃ for 30 minutes and intraperitoneal in jection of platinum diaminodichloride at 3.5mg/kg.The results showed that the effect of treatment ranked in the following order:irradiation combined with hyperthermia and chemotherapy>irradiation plus hyperthermia>chemotherapy or hyperthermia alone.The tumor regression rates were 91.6%,80.4%,29.9% and 33.7%,respectively (P<0.01). |
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