| Zhao yongliang,Jin Cuizhen,Liu Guolian,et al.Neoplastic transformation of primary rat tracheal epithelial cells in culture induced by irrad iation with α-particles[J].Chinese Journal of Radiological Medicine and Protection,1996,16(4):235-237 |
| Neoplastic transformation of primary rat tracheal epithelial cells in culture induced by irrad iation with α-particles |
| Received:March 31, 1995 Revised:July 20, 1995 |
| DOI： |
| KeyWords:238Pu ratstracheal cells neoplastic transformation |
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| Abstract:: |
| Serum-free cultures of primary rat tracheal epithelial (RTE) cells from specific pathogen-free Wistar rats were used to study the cytotoxic potency and tran sforming effects induced by irradiation with 238 Pu α-particles.The results showed that α-particles were substantially more effective than γ-rays.In terms of D37,the RBE of α-particles was 2.54.For transformation study,primary cell cultures received single exposure to 4Gyα-particles at a dose rate of 1.26Gy.min-1.By successive passaging,passage 40 cells produced invasive squamous cell carcinomas in two out of three animals with a latent period of 4 months upon inoculation into nude mice.This culture system is a useful model to study the mechanism of radiation carcinogenesis. |
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