| Luo Ying,Sun Zhixian.Role of topoisomerase Ⅰ,Ⅱ and poly(ADP-ribose) polymerase in cell radiosensitivity[J].Chinese Journal of Radiological Medicine and Protection,1996,16(4):232-234 |
| Role of topoisomerase Ⅰ,Ⅱ and poly(ADP-ribose) polymerase in cell radiosensitivity |
| Received:March 10, 1995 Revised:July 25, 1995 |
| DOI： |
| KeyWords:Cell radiosensitivity topoisomerase poly ADP-ribose polymerase |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| TopoisomeraseⅠ,Ⅱ and poly(ADP-ribose) polymerase are key enzymes in regulation of chromosome structure and play important roles in DNA replication,RNA transcription and DNA damage repair.We used an orthogonal design to analyze the role of topoisonoraseⅠ,Ⅱ and poly(ADP-ribose) polymerase in the regulation of chromosome structure and the production of DNA damages after irradiation.It was observed that their inhibitors could loose chromosome structure and increase DNA damages in irradiated cells,and they interacted with each other.This result shows that these three enzymes facilitate the integrity of chromosome structure and promote radioresistant ability of cells.The interaction between these three enymes reflects their internal relation. |
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