| Ran Xinze,Yan Yongtang,Cheng Tianmin,et al.Effects of combined radiation-burn injury on survival rate of allogeneic skin grafts and immune reaction in rats[J].Chinese Journal of Radiological Medicine and Protection,1996,16(4):228-231 |
| Effects of combined radiation-burn injury on survival rate of allogeneic skin grafts and immune reaction in rats |
| Received:February 13, 1995 Revised:August 14, 1995 |
| DOI： |
| KeyWords:Combined radiation-bur n injury allogeneic skin graft radiation dose immune reaction |
| FundProject: |
| Author Name | Affiliation | | Ran Xinze | Combined Injury Research Section, Faculty of Preventive Medicine, Third Military Medical University, Chongqing, 630038 | | Yan Yongtang | Combined Injury Research Section, Faculty of Preventive Medicine, Third Military Medical University, Chongqing, 630038 | | Cheng Tianmin | Combined Injury Research Section, Faculty of Preventive Medicine, Third Military Medical University, Chongqing, 630038 | | 林远 | Combined Injury Research Section, Faculty of Preventive Medicine, Third Military Medical University, Chongqing, 630038 | | 魏书庆 | Combined Injury Research Section, Faculty of Preventive Medicine, Third Military Medical University, Chongqing, 630038 |
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| Abstract:: |
| The effects of combined radiation-burn injury on survival rate of allogeneic skin grafts and immune reaction were studied in rats with combined injury of 3-8Gy 60Co γ-ray irradiation plus 15% total body surface area full thickness burn induced by exposure to a 5kW bromotungsten lamp.The allogeneic skin was transplanted 24 hours after injury.It was found that all the skin grafts failed to survive in 10 days and the immune reaction significantly increased in the early stage of burn injury.But the immune reaction was obviously suppressed by the combined radiation-burn injury.The survival rates of skin grafts were 20% and 30% in the combined injury of bum plus 3 and 4Gy irradiation respectively.When the radiation doses increased to 5,6 and 8Gy,the survival rates elevated to 69%,88% and 100% respectively(in the group of 8Gy,bone marrow transplantation was conducted before receiving skin graft).At day 30 post-transplantation the survival rates were still 36%,42% and 100% respectively.Compared with burn group,there was a significant difference in survival rate when the radiation doses were higher then 5Gy.These results indicate that the survival rate of the allogeneic skin graft increases concurrently with the increase in radiation dose and decreases with the elapse of the post-transplantaion time. |
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