Zhao Po,Wang Dewen,Gao Yabing,et al.Overexpression of MDM2 and p53 proteins in human radiation-induced skin ulcer[J].Chinese Journal of Radiological Medicine and Protection,1996,16(4):223-224
Overexpression of MDM2 and p53 proteins in human radiation-induced skin ulcer
Received:September 14, 1995  Revised:December 22, 1995
DOI：
KeyWords:Skin ulcer  radiation  oncogene
FundProject:国家自然科学基金
Author NameAffiliation
Zhao Po 100850 北京放射医学研究所病理学研究室 
Wang Dewen 解放军总医院病理科 
Gao Yabing 解放军总医院病理科 
熊呈琦 解放军总医院病理科 
杨志祥 北京北太平路医院 
李国民 北京北太平路医院 
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Abstract::
      We used MDM2 and p53 monoclonal antibodies and immunohistochemical method to study 25 cases of human radiation-induced skin ulcer.It was found that the positive rate for overexpression of MDM2 was 36% (9/25)and for that of p53 was only 8% (2/25).The result suggests that the molecular pathological changes in MDM2 and p53,genes and proteins might be involved in cancer transformation of human radiationinduced skin ulcer.
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