| Du Yuejiao,Wang Dewen,Gao Yabing,et al.A pathological study on overexpression of c-fos and Rb proteins in human radiation skin ulcer[J].Chinese Journal of Radiological Medicine and Protection,1996,16(4):220-222 |
| A pathological study on overexpression of c-fos and Rb proteins in human radiation skin ulcer |
| Received:January 15, 1996 Revised:March 30, 1996 |
| DOI： |
| KeyWords:Radiation skin injury oncogene pathology |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| We performed an immunohistochemical study on human radiation skin ulcer by using antibodies against c-fos and Rb proteins and antigen-repairing method with a microwave oven.We found that the positive rates of overexpression of c-fos and Rb proteins were 84.0% and 100%,respectively.The overexpression of c-fos protein was mainly observed in cell nuclei of squamous epithelial cells,fibroblasts,endothelial cells,and leiomyocytes in media and fibrocytes in adventitia of arterioles.The location of the Rb protein overexpression was mostly similar to that of c-fos protein.The overexpression of c-fos and Rb proteins may be related to cancer transformation and poor healing of radiation-induced skin ulcers. |
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