| Luo Qingliang,Xia Zhenbiao,Dong Bo.Haematological effects of rhG-CSF on dogs exposed to 6.5Gy uneven γ-radiation[J].Chinese Journal of Radiological Medicine and Protection,1996,16(3):170-172 |
| Haematological effects of rhG-CSF on dogs exposed to 6.5Gy uneven γ-radiation |
| Received:March 21, 1995 Revised:July 14, 1995 |
| DOI： |
| KeyWords:rhG-CSF neutropenia acute radiation sickness uneven irradiation |
| FundProject: |
| Author Name | Affiliation | | Luo Qingliang | Institute of Radiation Medicine, Beijing, 100850 | | Xia Zhenbiao | Institute of Radiation Medicine, Beijing, 100850 | | Dong Bo | Institute of Radiation Medicine, Beijing, 100850 | | 从玉文 | Institute of Radiation Medicine, Beijing, 100850 | | 张浩 | Institute of Radiation Medicine, Beijing, 100850 | | 白蕴红 | Institute of Radiation Medicine, Beijing, 100850 | | 王德文 | Institute of Radiation Medicine, Beijing, 100850 | | 毛秉智 | Institute of Radiation Medicine, Beijing, 100850 |
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| Abstract:: |
| The stimulative effects of recombinant human granulocyte colony stimulating factor(rhG-CSF)on haematopoietic regeneration were studied in dogs receiving an uneven γ-irradiation with the pelvis shielded at a dose of 6.5Gy.In the treated dogs, intravenous administration of rhG-CSF at 5 or 10μg/kg per day for 16 to 20 days caused significant increases of peripheral blood leucocytes, neutrophils, reticulocytes, and platelets.The nucleated cell and CFU-GM cornts of bone marrow also showed an obvious rise, while the hemoglobin level did not significantly change during the course of treatment.In the irradiated dogs treated with rhG-CSF, the severity of neutropenia decreased, and its duration shortened. |
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