| Cao Zhenshan,Ye Changqing,Yuan Lizhen.Morphometric changes of pulmonary tissues after 20Gy external irradiation of rat chest[J].Chinese Journal of Radiological Medicine and Protection,1996,16(3):167-169 |
| Morphometric changes of pulmonary tissues after 20Gy external irradiation of rat chest |
| Received:March 21, 1995 Revised:July 14, 1995 |
| DOI： |
| KeyWords:Morphometric parameters gamma irradiation pulmonary tissues |
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| Abstract:: |
| The changes in the main parameters of the lungs at different periods of early stage after local 20Gy external irradiation of the lungs were measured with morphometric method.The results indicated that the walls of pulmonary arterioles and venules thickened and the vascular permeability index(area of vascuiar lumen/total area of blood vessel) decreased 7 days after irradiation(P<0.05).Regression analysis of the vascular wall thickness and the vascular permeability index revealed that the two parameters had negative correlation(Y=1.38-0.198X+0.01X2, r=-0.919), indicating that narrowing of the vascular lumen was the result of thickening of the vascular wall.Fifteen days after irradiation, the pulmonary alveolar wall thickened, the area of alveolar cavity decreased and the area of pulmonary interstitial space increased(P<0.01).Electronmicroscopic examination demonstrated profuse exudation surrounding the microvessels, obvious evacuation of pulmonary type-Ⅱcells and increase in cellular types and quantity of pulmonary tissues. |
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