Jin Weifang,Zhu Wenijing,Wang Hongfu,et al.Establishing an ageing model of osteoblasts with137Cs γ-ray irradiation[J].Chinese Journal of Radiological Medicine and Protection,1996,16(3):164-166
Establishing an ageing model of osteoblasts with137Cs γ-ray irradiation
Received:March 21, 1995  Revised:July 14, 1995
DOI：
KeyWords:osteoblasts  gamma irradiation  ageing model
FundProject:国家自然科学基金
Author NameAffiliation
Jin Weifang 200032 上海医科大学老年医学研究中心 
Zhu Wenijing 200032 上海医科大学老年医学研究中心 
Wang Hongfu 200032 上海医科大学老年医学研究中心 
关本博 日本金医科大学老年病教室 
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Abstract::
      137Cs γ-rays were used to irradiate cultured osteoblasts in vitro.Degenerative changes in shape, disorders in function and proliferation of osteoblasts were observed.After irradiation with a single dose of 6.0Gy, the activity of owteoblast ALP and the rate of proliferation were inhibited by 28% and 48.2% respectively.The degeneration of osteoblasts exposed to γ-rays was similar to the natural ageing of cells.It is suggested that γ-irradiation may accelerate the ageing process of osteoblasts.This method may be used for establishing the cell model for the research of drugs to delay osteoblast ageing.
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