| Sun Chengwen,An Gang,Zhong Guogan,et al.Effect of low dose X-rays on Ca2+-activated K+ channels in mouse thymic lymphocytes[J].Chinese Journal of Radiological Medicine and Protection,1996,16(3):154-156 |
| Effect of low dose X-rays on Ca2+-activated K+ channels in mouse thymic lymphocytes |
| Received:March 21, 1995 Revised:July 14, 1995 |
| DOI： |
| KeyWords:Patch clamp Ca2+-activated K+ channel low dose radiation thymic lymphocytes immunoenhancement |
| FundProject:国家自然科学基金 |
|
| Hits: 3766 |
| Download times: 2039 |
| Abstract:: |
| The effect of low dose X-rays on Ca2+-activated K+ channels[K(ca)] in mouse thymic lymphocytes was observed using the cell-attached configuration of patch clamp technique.It is shown that low dose X-rays can elevate the open times and openstate probabilities of K(ca) channels, without apparent influence on the current flowing through the channels.After 3 min exposure of lymphocytes to Con A the open-state probabilitis of K(ca) channels in irradiated group were higher than those in control group.It was observed that from 4 to 24h after irradiation the activity of K(ca) chanels increased with time. K(ca)channels are important in the molecular mechanism of immutnoenhancement following low dose irradiation. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
